31 Jul '16, 3am

Singapore scientists grow mini human brains > Agency for Science Technology and Research (A*STAR) > Press Releases

A midbrain organoid in a petri dish. The black pigment is neuromelanin, a hallmark of the human midbrain. The human midbrain, which is the information superhighway, controls auditory, eye movements, vision and body movements. It contains special dopaminergic neurons that produce dopamine – which carries out significant roles in executive functions, motor control, motivation, reinforcement, and reward. High levels of dopamine elevate motor activity and impulsive behaviour, whereas low levels of dopamine lead to slowed reactions and disorders like PD, which is characterised by stiffness and difficulties in initiating movements. Also causing PD is the dramatic reduction in neuromelanin production, leading to the degenerative condition of patients, which includes tremors and impaired motor skills. This creation is a key breakthrough for studies in PD, which affects an estimate...

Full article: https://www.a-star.edu.sg/Media/News/Press-Releases/artic...

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