19 Apr '17, 2pm

Singapore scientists provide new insights on how cancers evade the immune system

Singapore scientists provide new insights on how cancers evade the immune system

A team of scientists from Singapore has discovered new ways in which cancers can escape the body's immune system. Focusing on gastric cancer (GC), the third leading cause of cancer death worldwide, the team's findings may also prove applicable to other major cancers with potential implications for how cancers might be better treated with immunotherapy, one of the most promising classes of anti-cancer drugs today. Promoters are regions in the genome that regulate the expression of genes, similar to the switch of a light bulb. Using an ultra-sensitive technique called NanoChIP-seq, the team surveyed the promoter landscape for GC to better understand the epigenetic mechanisms contributing to GC development. The team found that in GCs, gene promoters are dysregulated in a way that alters a tumour's antigenic profile to evade the body's immune system. The study, published in th...

Full article: https://scienmag.com/singapore-scientists-provide-new-ins...

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