30 Nov '17, 8am

Dengue vaccine can be dangerous for those not previously infected, says manufacturer

SINGAPORE - Dengvaxia, a dengue vaccine available here since March, could prove detrimental to people who have never been infected by dengue. Sanofi, which produces the vaccine, sent out an alert saying: "For those not previously infected by dengue virus, the analysis found that in the longer term, more cases of severe disease could occur following vaccination upon a subsequent dengue infection." The French pharmaceutical giant said it will ask the health authorities in countries where it has been approved for use, such as in Singapore, to update their information on the vaccine. A spokesman for the Health Sciences Authority (HSA) said on Thursday (Nov 30) that it is working with Sanofi Pasteur to "strengthen the package insert" to include the warning of an increased risk of hospitalisation for dengue and clinically severe dengue in vaccinated individuals not previously in...

Full article: http://www.straitstimes.com/singapore/health/dengue-vacci...

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